Excerpt from:

The Latest Wrinkle - Fixers
By Janet Carlson Freed

There's much to be said for the new facial-line fillers - but don't ignore these caveats from the experts.

Until just recently in the antiaging field, all eyes were on Botox, the botulinum toxin that doctors inject to temporarily paralyze wrinkle-causing muscles. Lately I've been hearing a great deal about other "injectables," including Restylane, Perlane, Radiance, Silikon 1000 and Artecoll. These line fillers seem promising, but they're new and therefore unproven. I spoke with six dermatologists and plastic surgeons to find out what they think is the best news about these parasurgical treatments and what we should be cautious about. Procedures range from $500 to $1,500; more permanent methods are costlier.

John E. Sherman, plastic surgeon, NYC
Good news: I like the idea of an elegant layering of fillers: CosmoDerm first, to fill superficial lines. Because it contains lidocaine, it anesthetizes the area. Restylane, once approved, could be injected in the deeper folds (this is more painful).
Caveat: You need to be cautious with the eye area. In rare cases, periorbital injections can occlude vision. There have been a handful of reports resulting in blindness.

What's What In Injectables
Artecoll: Microscopic beads of plastic in a bovine-collagen solution; under FDA review. Semipermanent. Cosmoderm/Cosmoplast: Human collagen manufactured from skin tissue in a lab; FDA approved for cosmetic use; minimal potential for allergic reaction. Lasts three to six months. Fat: Aspirated from your own thighs or buttocks, treated and injected into lines between your nose and mouth or around your cheeks. Lasts six month to permanently. Perlane/Restylane: Lab-produced hyaluronic acid (found naturally in the body); Restylane is under FDA review. Perlane (not FDA-approved) is a denser form of Restylane, used for cheekbones, chins and deeper folds. Lasts six to nine months. Radiance: Calcium hydroxiapatite (found naturally in teeth and bones); not FDA-approved for cosmetic use; used off-label (meaning it's approved for other conditions). Semipermanent. Silikon 1000: Silicone oil; not yet FDA-approved for cosmetic use but it is used off-label. Permanent.